Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 7/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 5/20 | 0.44 |
| ▸ | HTR1B | P28222 | 4/20 | 0.44 |
| ▸ | HTR1F | P30939 | 3/20 | 0.44 |
| ▸ | HTR1D | P28221 | 3/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8298950 | 0.96 | MEN1 (0.47) | MEN1HTTKMT2ADRD4CCR2 | |
| SCHEMBL8298661 | 0.93 | MEN1 (0.50) | MEN1HTTKMT2ACCR2HTR1A | |
| SCHEMBL8299246 | 0.89 | HTR1A (0.48) | MEN1HTTKMT2AHTR1AHTR1B | |
| SCHEMBL8296229 | 0.86 | DRD2 (0.54) | MEN1HTTKMT2ADRD4DRD2 | |
| SCHEMBL7845970 | 0.86 | KMT2A (0.58) | MEN1HTTKMT2ADRD4DRD2 | |
| SCHEMBL8303265 | 0.82 | HTR1D (0.52) | HTTDRD4DRD2HTR1AHTR1B | |
| SCHEMBL8299590 | 0.82 | DRD2 (0.51) | MEN1HTTKMT2ADRD2HTR1A | |
| SCHEMBL8305897 | 0.81 | CYP2D6 (0.44) | CCR2DRD2HTR1AKCNH2 | |
| SCHEMBL8296251 | 0.81 | OPRM1 (0.53) | MEN1HTTKMT2ADRD2HTR1A | |
| SCHEMBL8304106 | 0.80 | DRD4 (0.53) | DRD4HTR1BHTR1DRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1223650-A | Piperidines and pyrrolidines | MERCK PATENT GMBH (DE) | 1999-07-21 | — | — | CN | disclosed |
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |