Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.67 |
| ▸ | ADK | P55263 | 2/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8523300 | 0.89 | ADK (0.61) | SLC29A1ADK | |
| SCHEMBL8464085 | 0.88 | ADK (0.73) | SLC29A1ADKADORA1ADORA3ADORA2A | |
| SCHEMBL8469111 | 0.88 | SLC29A1 (0.68) | SLC29A1ADKADORA1ADORA3ADORA2A | |
| SCHEMBL6758644 | 0.80 | SLC29A1 (0.98) | SLC29A1ADORA1ADORA3ADORA2A | |
| SCHEMBL31628603 | 0.80 | SLC29A1 (0.98) | SLC29A1ADORA1ADORA3ADORA2A | |
| SCHEMBL8328951 | 0.80 | SLC29A1 (0.98) | SLC29A1ADORA1ADORA3ADORA2A | |
| SCHEMBL25048779 | 0.79 | ADK (0.75) | SLC29A1ADKHIF1APAX8 | |
| SCHEMBL8523567 | 0.77 | SLC29A1 (0.66) | SLC29A1ADORA1ADORA3ADORA2A | |
| SCHEMBL8461010 | 0.76 | ADK (0.68) | SLC29A1ADK | |
| SCHEMBL8466994 | 0.76 | ADK (0.62) | SLC29A1ADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496617-B1 | Adenosine kinase inhibitors | METABASIS THERAPEUTICS INC (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5646128-A | TREATING INFLAMMATION, SEPSIS, SEPTIC SHOCK, BURNS | GENSIA, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| WO-1994017803-A9 | ADENOSINE KINASE INHIBITORS | — | 1994-09-29 | — | — | WO | disclosed |
| WO-1992012718-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1992-08-06 | — | — | WO | disclosed |
| EP-0496617-A1 | Adenosine kinase inhibitors | GENSIA, INC. (US) | 1992-07-29 | — | — | EP | disclosed |