Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 3/20 | 0.66 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29600893 | 0.84 | ADK (0.58) | — | |
| SCHEMBL30047434 | 0.82 | ADA (0.52) | ALDH1A1LMNATP53SMN1; SMN2 | |
| SCHEMBL29601078 | 0.82 | ATG7 (0.53) | SLC29A1ADORA1ADORA3ADORA2AALDH1A1 | |
| SCHEMBL11210320 | 0.81 | SLC29A1 (0.48) | SLC29A1ADORA3 | |
| SCHEMBL30935808 | 0.80 | SLC29A1 (0.52) | SLC29A1 | |
| SCHEMBL29273715 | 0.80 | SLC29A1 (0.52) | SLC29A1 | |
| SCHEMBL8975931 | 0.79 | ADK (0.71) | SLC29A1NPC1ALDH1A1LMNATSHR | |
| SCHEMBL6758644 | 0.79 | SLC29A1 (0.98) | SLC29A1ADORA1ADORA3ADORA2ATSHR | |
| SCHEMBL8328951 | 0.79 | SLC29A1 (0.98) | SLC29A1ADORA1ADORA3ADORA2ATSHR | |
| SCHEMBL31628603 | 0.79 | SLC29A1 (0.98) | SLC29A1ADORA1ADORA3ADORA2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496617-B1 | Adenosine kinase inhibitors | METABASIS THERAPEUTICS INC (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5646128-A | TREATING INFLAMMATION, SEPSIS, SEPTIC SHOCK, BURNS | GENSIA, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| WO-1992012718-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1992-08-06 | — | — | WO | disclosed |
| EP-0496617-A1 | Adenosine kinase inhibitors | GENSIA, INC. (US) | 1992-07-29 | — | — | EP | disclosed |