Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8524315 | 0.77 | FFAR1 (0.53) | MAPTKDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8523431 | 0.75 | POLB (0.37) | MAPTTP53PTPN7THRBALDH1A1 | |
| SCHEMBL6032172 | 0.69 | MAPT (0.53) | MAPTKDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8523852 | 0.67 | ALDH1A1 (0.44) | MAPTKDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8523887 | 0.66 | MAPT (0.43) | MAPTKDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7469293 | 0.66 | MAPT (0.56) | MAPTKDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6090918 | 0.66 | CREBBP (0.58) | MAPTKDM4EALDH1A1APEX1 | |
| SCHEMBL27516237 | 0.65 | MAPT (0.51) | MAPTKDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8687360 | 0.64 | PPARG (0.48) | MAPTKDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8472101 | 0.64 | MAPT (0.41) | MAPTKDM4ECYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834501-A | TREATING DIABETES OR HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 1998-11-10 | — | — | US | claimed |
| US-5962470-A | Heterocyclic compounds having anti-diabetic activity and their use | SANKYO COMPANY, LIMITED (JP) | 1999-10-05 | — | — | US | disclosed |