Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834886 | 0.76 | MEN1 (0.37) | ALDH1A1KMT2AMEN1USP2CDK4 | |
| SCHEMBL6032172 | 0.72 | MAPT (0.53) | ALDH1A1KMT2AMAPTKDM4EPOLB | |
| SCHEMBL8523856 | 0.72 | ALDH1A1 (0.44) | ALDH1A1KMT2AMEN1USP2CDK4 | |
| SCHEMBL8523887 | 0.72 | MAPT (0.43) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL8524315 | 0.72 | FFAR1 (0.53) | ALDH1A1KMT2ACDK4CCND1MAPT | |
| SCHEMBL30385807 | 0.71 | HRH3 (0.59) | ALDH1A1KMT2AMEN1ALOX15MAPT | |
| SCHEMBL291316 | 0.71 | HRH3 (0.59) | ALDH1A1KMT2AMEN1ALOX15MAPT | |
| SCHEMBL7469293 | 0.70 | MAPT (0.56) | KMT2AMEN1MAPTKDM4EPOLB | |
| SCHEMBL8687360 | 0.70 | PPARG (0.48) | ALDH1A1MAPTKDM4EL3MBTL1NPC1 | |
| SCHEMBL8523430 | 0.67 | MAPT (0.36) | ALDH1A1KMT2AMEN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834501-A | TREATING DIABETES OR HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 1998-11-10 | — | — | US | claimed |
| US-5962470-A | Heterocyclic compounds having anti-diabetic activity and their use | SANKYO COMPANY, LIMITED (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5739345-A | HYPOGLYCEMIC AND ANTIDIABETIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1998-04-14 | — | — | US | disclosed |