SCHEMBL852348

SCHEMBL852348

C=C(C)COC[Si](C)(C)Oc1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR174 Q9BXC1 1/20 0.37
PAX8 Q06710 1/20 0.36
MEN1 O00255 5/20 0.33
KMT2A Q03164 5/20 0.33
MAPT P10636 2/20 0.33
NPSR1 Q6W5P4 2/20 0.33
LMNA P02545 2/20 0.33
ALOX12 P18054 1/20 0.33
ALOX15 P16050 2/20 0.32
POLB P06746 2/20 0.32
KDM4E B2RXH2 1/20 0.32
USP2 O75604 1/20 0.32
TP53 P04637 1/20 0.32
MAPK1 P28482 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HSD17B10 Q99714 1/20 0.32
TRPM8 Q7Z2W7 1/20 0.31
ALDH1A1 P00352 1/20 0.31
PKM P14618 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3914281 0.85 GPR174 (0.38) GPR174PAX8MEN1KMT2AMAPT
SCHEMBL852399 0.81 L3MBTL1 (0.35) GPR174PAX8MEN1KMT2AMAPT
SCHEMBL9807655 0.79 PAX8 (0.40) GPR174PAX8MEN1KMT2AMAPT
SCHEMBL840792 0.76 MAPT (0.41) GPR174PAX8MEN1KMT2AMAPT
SCHEMBL4444485 0.75 L3MBTL1 (0.35) GPR174PAX8MEN1KMT2AMAPT
SCHEMBL231730 0.74 ELANE (0.42) GPR174PAX8MAPTALOX15POLB
SCHEMBL6116693 0.74 GPR174 (0.40) GPR174PAX8MEN1KMT2AMAPT
SCHEMBL8899639 0.73 L3MBTL1 (0.36) GPR174PAX8MEN1KMT2AMAPT
SCHEMBL1857566 0.73 L3MBTL1 (0.36) GPR174PAX8MEN1KMT2AMAPT
SCHEMBL27941778 0.72 CA4 (0.42) LMNAKDM4ETP53SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8247590-B2 Method for preventing polymerization of unsaturated organosilicon compounds WACKER CHEMIE AG (DE) 2012-08-21 US disclosed
EP-2334690-B1 METHOD FOR PRODUCING (METH)ACRYLOSILANES WACKER CHEMIE AG (DE) 2012-07-25 EP disclosed
EP-2300486-B1 METHOD FOR PREVENTING POLYMERIZATION OF UNSATURATED ORGANOSILICON COMPOUNDS WACKER CHEMIE AG (DE) 2012-03-28 EP disclosed
US-20110118493-A1 METHOD FOR PREVENTING POLYMERIZATION OF UNSATURATED ORGANOSILICON COMPOUNDS WACKER CHEMIE AG (DE) 2011-05-19 US disclosed
US-7619108-B2 Process for preparing unsaturated organosilicon compounds WACKER CHEMIE AG (DE) 2009-11-17 US disclosed
EP-1954701-B1 PROCESS FOR PREPARING UNSATURATED ORGANOSILICON COMPOUNDS WACKER CHEMIE AG (DE) 2009-03-18 EP disclosed
US-20080293958-A1 Process for Preparing Unsaturated Organosilicon Compounds WACKER CHEMIE AG (DE) 2008-11-27 US disclosed
US-6815554-B2 REACTING A HALOALKYLSILANE WITH A SALT OF AN UNSATURATED CARBOXYLIC ACID IN THE PRESENCE OF A PHASE TRANSFER CATALYST; BONDING AGENTS WACKER-CHEMIE GMBH (DE) 2004-11-09 US disclosed
EP-1469002-A1 Method for stabilizing unsaturated organo-silicon compounds Wacker-Chemie GmbH (DE) 2004-10-20 EP disclosed
US-20020151736-A1 PROCESS FOR PREPARING UNSATURATED ORGANOSILICON COMPOUNDS WACKER-CHEMIE GMBH (DE) 2002-10-17 US disclosed
EP-1249454-A1 Preparation of unsaturated organo-silicon compounds Wacker-Chemie GmbH (DE) 2002-10-16 EP disclosed