Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13284828 | 0.72 | DRD2 (0.70) | HRH3HTR7LMNAMEN1SLC22A2 | |
| SCHEMBL8524117 | 0.71 | PLD2 (0.36) | HRH3OPRM1PLD2PLD1DAO | |
| SCHEMBL27246575 | 0.70 | HTR7 (0.60) | HTR7LMNAHTR1AP2RX7 | |
| SCHEMBL8130804 | 0.69 | LMNA (0.55) | HTR7LMNAMEN1SLC22A2NR1I2 | |
| SCHEMBL2615288 | 0.69 | DRD2 (0.79) | HRH3HTR7LMNAMEN1SLC22A2 | |
| SCHEMBL4084811 | 0.68 | DAO (0.55) | LMNAMEN1CYP1A2CYP3A4ADORA3 | |
| SCHEMBL6844257 | 0.68 | HTR7 (0.50) | HRH3HTR7LMNAHTR1ADRD2 | |
| SCHEMBL2615289 | 0.68 | DRD2 (0.63) | HRH3HTR7LMNAMEN1SLC22A2 | |
| Flumeridone SCHEMBL636160 | 0.68 | DRD2 (0.80) | HTR7LMNAMEN1SLC22A2NR1I2 | |
| Flumeridone SCHEMBL11520064 | 0.67 | DRD2 (0.79) | HTR7LMNAMEN1SLC22A2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889010-A | PSYCHOLOGICAL DISORDERS; UROGENITAL DISORDERS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; VISION DEFECTS; CONGESTIVE HEART FAILURE; DRUG ABRUSE; PARKINSON'S DISEASE;ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | PFIZER INC. (US) | 1999-03-30 | — | — | US | disclosed |