Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29960387 | 0.84 | CRBN (0.47) | CRBNDDB1NPC1MAPK13MAPK12 | |
| SCHEMBL25789187 | 0.83 | BRD4 (0.57) | BRD4CREBBPALDH1A1MAPTHTR5A | |
| SCHEMBL29960334 | 0.83 | CRBN (0.43) | CRBNDDB1NPC1MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL29960573 | 0.83 | CRBN (0.46) | CRBNDDB1NPC1MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL29960240 | 0.82 | CRBN (0.42) | CRBNDDB1NPC1MAPK13MAPK12 | |
| SCHEMBL29960386 | 0.80 | CRBN (0.43) | CRBNDDB1NPC1MAPK13MAPK12 | |
| SCHEMBL5025547 | 0.80 | ALDH1A1 (0.50) | CRBNDDB1NPC1MAPK13MAPK12 | |
| SCHEMBL29960465 | 0.80 | CRBN (0.40) | CRBNDDB1NPC1MAPK13MAPK12 | |
| SCHEMBL1347194 | 0.78 | DDB1 (0.49) | CRBNDDB1BRD4CREBBPNPC1 | |
| SCHEMBL6441308 | 0.76 | CRBN (0.44) | CRBNDDB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508484-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2021-04-07 | — | — | EP | disclosed |
| WO-1999015524-A1 | THIAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-04-01 | — | — | WO | disclosed |