Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 12/20 | 0.68 |
| ▸ | MMP2 | P08253 | 8/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MMP1 | P03956 | 7/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.54 |
| ▸ | MMP3 | P08254 | 2/20 | 0.52 |
| ▸ | MMP13 | P45452 | 4/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.51 |
| ▸ | MMP14 | P50281 | 1/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308416 | 0.80 | MMP9 (0.95) | MMP9MMP2MMP1ADAM17MMP3 | |
| SCHEMBL7308413 | 0.80 | MMP9 (0.95) | MMP9MMP2MMP1ADAM17MMP3 | |
| SCHEMBL6336581 | 0.79 | RAB9A (0.84) | RAB9AADAM17 | |
| SCHEMBL6336577 | 0.79 | RAB9A (0.84) | RAB9AADAM17 | |
| SCHEMBL6336575 | 0.79 | RAB9A (0.84) | RAB9AADAM17 | |
| SCHEMBL8483590 | 0.79 | MMP2 (0.55) | MMP9MMP2RAB9AMMP1ADAM17 | |
| SCHEMBL8524352 | 0.78 | MMP9 (0.72) | MMP9MMP2MMP1MMP3MMP13 | |
| SCHEMBL7305533 | 0.77 | MMP9 (1.00) | MMP9MMP2MMP1MMP3MMP13 | |
| SCHEMBL7305528 | 0.77 | MMP9 (1.00) | MMP9MMP2MMP1MMP3MMP13 | |
| SCHEMBL6335888 | 0.77 | RAB9A (0.80) | MMP9MMP2RAB9AADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883131-A | Cyclic sulfone derivatives | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0818442-A2 | Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor | PFIZER INC. (US) | 1998-01-14 | — | — | EP | disclosed |