Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | CASP2 | P42575 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10838349 | 0.89 | CYP11B1 (0.42) | MAPTALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL4882731 | 0.87 | SMYD3 (0.55) | MAPTALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL10861761 | 0.87 | MAPT (0.46) | MAPTALDH1A1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL7317599 | 0.86 | CYP11B2 (0.44) | MAPTALDH1A1KDM4ECYP11B1CYP11B2 | |
| SCHEMBL4856652 | 0.85 | CYP11B2 (0.40) | MAPTALDH1A1SMN1; SMN2KDM4ECYP11B1 | |
| Hydrochloric Acid SCHEMBL10861752 | 0.84 | SIRT2 (0.45) | MAPTALDH1A1KDM4ECYP11B1CYP11B2 | |
| SCHEMBL10563001 | 0.84 | TMEM97 (0.46) | MAPTLMNACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL9366492 | 0.83 | ATAD2 (0.58) | MAPTALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL27611336 | 0.82 | HSD17B3 (0.44) | MAPTALDH1A1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL20894244 | 0.82 | LMNA (0.56) | MAPTALDH1A1LMNACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3277678-B1 | COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS | NANTBIO INC (US) | 2020-03-18 | — | — | EP | disclosed |
| US-20180086752-A1 | COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS | NANTBIO, INC. | 2018-03-29 | — | — | US | disclosed |
| WO-1999015524-A1 | THIAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-04-01 | — | — | WO | disclosed |
| WO-1991000863-A1 | HETEROARYL PIPERAZINE ANTIPSYCHOTIC AGENTS | PFIZER INC. (US) | 1991-01-24 | — | — | WO | disclosed |
| US-4678785-A | CARDIOTONICS, ANTICOAGULANTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1987-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086752-A1 | COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS | KRAS, NRAS, HRAS | MAPT 4029/4885ALDH1A1 4472/4885SMN1; SMN2 3468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.