Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | CASP2 | P42575 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8524330 | 0.87 | MAPT (0.52) | SMYD3MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19357099 | 0.85 | SMYD3 (0.52) | SMYD3MAPTALDH1A1TRIM24GAA | |
| Hydrochloric Acid SCHEMBL10855737 | 0.84 | SMYD3 (0.54) | SMYD3MAPTALDH1A1TRIM24GAA | |
| SCHEMBL11319049 | 0.84 | SMYD3 (0.51) | SMYD3ALDH1A1TRIM24GAALMNA | |
| SCHEMBL4894332 | 0.83 | BRD4 (0.48) | SMYD3MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8483191 | 0.82 | ALDH1A1 (0.44) | SMYD3MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19357202 | 0.81 | MAPT (0.60) | SMYD3MAPTALDH1A1NPC1TRIM24 | |
| SCHEMBL31348187 | 0.81 | SMYD3 (0.60) | SMYD3MAPTALDH1A1TRIM24GAA | |
| SCHEMBL1965892 | 0.81 | SMYD3 (0.60) | SMYD3MAPTALDH1A1TRIM24GAA | |
| SCHEMBL3660693 | 0.80 | SMYD3 (0.59) | SMYD3MAPTALDH1A1SMN1; SMN2TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492785-B9 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | EP | disclosed |
| EP-1492785-B1 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-03 | — | — | EP | disclosed |
| US-20080269246-A1 | METHOD FOR TREATING PEDIATRIC BIPOLAR DISORDER | PFIZER INC | 2008-10-30 | — | — | US | disclosed |
| EP-1558608-A1 | OXINDOLE SUBSTITUTED PIPERAZINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-08-03 | — | — | EP | disclosed |
| US-20040142933-A1 | Oxindole substituted piperazine derivatives | FORREST GEORGE WILLIAM (CA) | 2004-07-22 | — | — | US | disclosed |
| WO-2004037820-A1 | OXINDOLE SUBSTITUTED PIPERAZINE DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2004-05-06 | — | — | WO | disclosed |
| EP-0985414-B1 | Medicament for the treatment of glaucoma and ischemic retinopathy | PFIZER PROD INC (US) | 2003-08-27 | — | — | EP | disclosed |
| US-6387904-B2 | COMPOUND CONTAINING PIPERAZINE RING | PFIZER INC | 2002-05-14 | — | — | US | disclosed |
| EP-0281309-B1 | PIPERAZINYL-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 1991-12-27 | — | — | EP | disclosed |
| EP-0281309-A1 | Piperazinyl-heterocyclic compounds | PFIZER INC. (US) | 1988-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142933-A1 | Oxindole substituted piperazine derivatives | OPRK1, OPRD1, CNR1 | SMYD3 2709/4885MAPT 611/4885ALDH1A1 181/4885 |
| US-20080269246-A1 | METHOD FOR TREATING PEDIATRIC BIPOLAR DISORDER | GABBR1, GABRR1, GABBR2 | SMYD3 674/4885MAPT 321/4885ALDH1A1 1399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.