Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 11/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27485384 | 1.00 | TAS2R14 (0.48) | TAS2R14LMNAMAPK1CNR2SMN1; SMN2 | |
| SCHEMBL8524504 | 0.90 | TAS2R14 (0.57) | TAS2R14LMNAMAPK1CNR2 | |
| SCHEMBL27561328 | 0.90 | TAS2R14 (0.57) | TAS2R14LMNAMAPK1CNR2 | |
| Bicarbonate SCHEMBL9058314 | 0.85 | PTGES (0.48) | TAS2R14LMNACNR2POLB | |
| SCHEMBL16558052 | 0.74 | MAPK1 (0.51) | MAPK1SMN1; SMN2POLBTDP1 | |
| SCHEMBL15534600 | 0.72 | HDAC1 (0.47) | TAS2R14LMNASMN1; SMN2 | |
| SCHEMBL1133773 | 0.70 | LMNA (0.59) | LMNASMN1; SMN2 | |
| SCHEMBL8484438 | 0.69 | GBA1 (0.70) | POLB | |
| SCHEMBL6774597 | 0.69 | TAS2R14 (0.47) | TAS2R14MAPK1SMN1; SMN2 | |
| SCHEMBL12077868 | 0.69 | TAS2R14 (0.52) | TAS2R14LMNACNR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922717-A | ANTICOAGULANTS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| CN-1183770-A | Piperazine derivatives, medicaments containing these compounds, their use and processes for their preparation | THOMAE GMBH DR K (DE) | 1998-06-03 | — | — | CN | disclosed |