Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8525129 | 0.99 | ATM (0.53) | ATMKMT2AALDH1A1TP53HPGD | |
| SCHEMBL15130041 | 0.85 | RAB9A (0.66) | KMT2AALDH1A1HTTTSHRRAB9A | |
| SCHEMBL8524702 | 0.85 | KMT2A (0.64) | ATMKMT2AALDH1A1TP53HPGD | |
| SCHEMBL8524617 | 0.83 | ATM (0.53) | ATMKMT2AALDH1A1TP53HPGD | |
| SCHEMBL8395852 | 0.80 | MAPK1 (0.55) | KMT2AALDH1A1TP53HPGDHTT | |
| SCHEMBL8392821 | 0.80 | GAA (0.59) | ATMKMT2AALDH1A1TP53HPGD | |
| Hydrochloric Acid SCHEMBL8396116 | 0.79 | GAA (0.58) | ATMKMT2AALDH1A1TP53HPGD | |
| SCHEMBL8394017 | 0.78 | LMNA (0.58) | KMT2AALDH1A1HPGDRAB9AMEN1 | |
| SCHEMBL8392950 | 0.78 | KDM1A (0.53) | ATMALDH1A1TP53RAB9APARP1 | |
| Hydrochloric Acid SCHEMBL8397090 | 0.78 | LMNA (0.57) | KMT2AALDH1A1HPGDRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | claimed |
| EP-0690851-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | Astra Aktiebolag (SE) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021621-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1994-09-29 | — | — | WO | disclosed |