Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.69 |
| ▸ | RXRB | P28702 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 3/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.57 |
| ▸ | BCR | P11274 | 3/20 | 0.57 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.52 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.52 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.52 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8469211 | 0.85 | RXRA (0.72) | RXRARXRBPTPN5MEN1KMT2A | |
| SCHEMBL14303566 | 0.84 | RXRA (0.66) | RXRARXRBPTPN5FFAR4SLC13A5 | |
| SCHEMBL8470898 | 0.82 | RXRA (0.64) | RXRARXRBABL1ABCB1BCR | |
| SCHEMBL8469680 | 0.82 | HSD17B1 (0.61) | RXRARXRBPTPN5MEN1ESR1 | |
| SCHEMBL27566569 | 0.81 | ABL1 (0.53) | RXRARXRBABL1ABCB1BCR | |
| SCHEMBL8523753 | 0.81 | CYP3A4 (0.66) | RXRARXRBABL1ABCB1BCR | |
| SCHEMBL863444 | 0.81 | ESR2 (0.58) | ABL1ABCB1BCRPTPN5MEN1 | |
| SCHEMBL24177866 | 0.79 | ABL1 (0.79) | ABL1ABCB1BCRMEN1ESR1 | |
| SCHEMBL1513611 | 0.79 | ABL1 (0.79) | ABL1ABCB1BCRMEN1ESR1 | |
| SCHEMBL2567825 | 0.79 | RXRA (0.60) | RXRARXRBPTPN5FFAR4SLC13A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999025707-A1 | 2-ARYLBENZO[b]THIOPHENES USEFUL FOR THE TREATMENT OF ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 1999-05-27 | — | — | WO | claimed |