Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGAV | P06756 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8468698 | 0.87 | KDM4E (0.44) | HSD17B10HTTKDM4EALDH1A1MAPT | |
| SCHEMBL7401262 | 0.84 | ITGB3 (0.42) | JAK2HSD17B10HTTEGFRKDM4E | |
| SCHEMBL7916963 | 0.83 | ITGB3 (0.51) | HSD17B10HTTEGFRKDM4EALDH1A1 | |
| SCHEMBL7916970 | 0.83 | ITGB3 (0.51) | HSD17B10HTTEGFRKDM4EALDH1A1 | |
| SCHEMBL7917615 | 0.83 | ITGB3 (0.41) | JAK2HSD17B10HTTEGFRKDM4E | |
| SCHEMBL8399397 | 0.82 | EPHX2 (0.44) | HSD17B10HTTKDM4EALDH1A1MAPT | |
| SCHEMBL7078802 | 0.82 | ITGB3 (0.49) | JAK2KDM4EMAPTITGB3ITGAV | |
| SCHEMBL4428402 | 0.79 | KDM4E (0.63) | HSD17B10HTTKDM4EALDH1A1MAPT | |
| SCHEMBL644092 | 0.79 | KDM4E (0.63) | HSD17B10HTTKDM4EALDH1A1MAPT | |
| SCHEMBL7399767 | 0.79 | ALDH1A1 (0.40) | ALDH1A1MAPTLMNAGAAITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964928-A1 | ENZYMATIC RESOLUTION OF BENZODIAZEPINE-ACETIC ACID ESTERS WITH A LIPASE | SMITHKLINE BEECHAM PLC (GB) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998029561-A1 | ENZYMATIC RESOLUTION OF BENZODIAZEPINE-ACETIC ACID ESTERS WITH A LIPASE | SMITHKLINE BEECHAM PLC (GB) | 1998-07-09 | — | — | WO | disclosed |