Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.61 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.60 |
| ▸ | DRD3 | P35462 | 4/20 | 0.57 |
| ▸ | DRD2 | P14416 | 3/20 | 0.57 |
| ▸ | DRD4 | P21917 | 3/20 | 0.57 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9092182 | 0.99 | SIGMAR1 (0.60) | SIGMAR1SSTR5DRD3DRD2DRD4 | |
| SCHEMBL8526596 | 0.90 | SIGMAR1 (0.75) | SIGMAR1DRD3DRD2DRD4 | |
| SCHEMBL8525826 | 0.86 | SIGMAR1 (0.57) | SIGMAR1DRD3DRD2DRD4HTR4 | |
| SCHEMBL8526305 | 0.83 | SSTR5 (0.52) | SIGMAR1SSTR5DRD3DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL8529638 | 0.82 | SSTR5 (0.51) | SIGMAR1SSTR5DRD3DRD2DRD4 | |
| SCHEMBL8526537 | 0.78 | SIGMAR1 (0.58) | SIGMAR1DRD3DRD2DRD4 | |
| SCHEMBL8525976 | 0.76 | SIGMAR1 (1.00) | SIGMAR1DRD3DRD2DRD4SLC6A12 | |
| SCHEMBL11938908 | 0.74 | ADRA1D (0.74) | SIGMAR1DRD4MEN1KMT2ASLC6A12 | |
| SCHEMBL8127075 | 0.73 | SIGMAR1 (0.75) | SIGMAR1DRD3DRD2 | |
| Hydrochloric Acid SCHEMBL9229456 | 0.72 | SIGMAR1 (0.52) | SIGMAR1SSTR5DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | claimed |
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | disclosed |
| EP-0539281-A1 | New naphthamides, process for their preparation and their application in the therapeutical field | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1993-04-28 | — | — | EP | disclosed |