Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.57 |
| ▸ | DRD3 | P35462 | 8/20 | 0.53 |
| ▸ | DRD2 | P14416 | 7/20 | 0.53 |
| ▸ | DRD4 | P21917 | 4/20 | 0.53 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8525768 | 0.86 | SIGMAR1 (0.61) | SIGMAR1DRD3DRD2DRD4HTR4 | |
| SCHEMBL8526596 | 0.86 | SIGMAR1 (0.75) | SIGMAR1DRD3DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL9092182 | 0.85 | SIGMAR1 (0.60) | SIGMAR1DRD3DRD2DRD4HTR4 | |
| SCHEMBL8526355 | 0.77 | MEN1 (0.66) | DRD3DRD2 | |
| SCHEMBL8119939 | 0.76 | SIGMAR1 (0.69) | SIGMAR1DRD3DRD2DRD4 | |
| SCHEMBL8967296 | 0.76 | DRD3 (0.51) | SIGMAR1DRD3DRD2 | |
| SCHEMBL8526305 | 0.76 | SSTR5 (0.52) | SIGMAR1DRD3DRD2DRD4HTR4 | |
| SCHEMBL7442570 | 0.75 | DRD2 (0.69) | SIGMAR1DRD3DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL8967334 | 0.75 | DRD3 (0.51) | SIGMAR1DRD3DRD2 | |
| Hydrochloric Acid SCHEMBL8529638 | 0.75 | SSTR5 (0.51) | SIGMAR1DRD3DRD2DRD4HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | claimed |
| EP-0539281-A1 | New naphthamides, process for their preparation and their application in the therapeutical field | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1993-04-28 | — | — | EP | claimed |
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | disclosed |
| US-5498628-A | ANTIPSYCHOTIC, PSYCHOSTIMULATORY, ANTIAUTISTIC, ANTIDEPRESSANT AND HYPOTENSIVE AGENTS, PARKINSON'S DISEASE | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-03-12 | — | — | US | disclosed |
| EP-0539281-A1 | New naphthamides, process for their preparation and their application in the therapeutical field | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1993-04-28 | — | — | EP | disclosed |