Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | DRD3 | P35462 | 13/20 | 0.64 |
| ▸ | DRD2 | P14416 | 11/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8525948 | 0.84 | DRD3 (0.78) | DRD3DRD2 | |
| SCHEMBL18186633 | 0.81 | MEN1 (0.58) | MEN1KMT2ADRD3DRD2LMNA | |
| SCHEMBL8526354 | 0.80 | DRD2 (0.43) | MEN1KMT2ADRD3DRD2SMN1; SMN2 | |
| SCHEMBL7442570 | 0.79 | DRD2 (0.69) | MEN1KMT2ADRD3DRD2LMNA | |
| SCHEMBL8967296 | 0.78 | DRD3 (0.51) | DRD3DRD2 | |
| Hydrochloric Acid SCHEMBL8967334 | 0.77 | DRD3 (0.51) | DRD3DRD2 | |
| SCHEMBL8525974 | 0.77 | PRMT5 (0.51) | DRD3DRD2LMNASMN1; SMN2KDM4E | |
| SCHEMBL8525826 | 0.77 | SIGMAR1 (0.57) | DRD3DRD2 | |
| SCHEMBL1186200 | 0.76 | LMNA (0.74) | MEN1KMT2ALMNACYP2C19SMN1; SMN2 | |
| SCHEMBL9246238 | 0.75 | LMNA (0.72) | MEN1KMT2ALMNACYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | claimed |
| EP-0539281-A1 | New naphthamides, process for their preparation and their application in the therapeutical field | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1993-04-28 | — | — | EP | claimed |
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | disclosed |
| US-5498628-A | ANTIPSYCHOTIC, PSYCHOSTIMULATORY, ANTIAUTISTIC, ANTIDEPRESSANT AND HYPOTENSIVE AGENTS, PARKINSON'S DISEASE | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-03-12 | — | — | US | disclosed |
| EP-0539281-A1 | New naphthamides, process for their preparation and their application in the therapeutical field | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1993-04-28 | — | — | EP | disclosed |