Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PHGDH | O43175 | 6/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501439 | 0.88 | TRPA1 (0.51) | MEN1KMT2APHGDHTRPA1CTSL | |
| SCHEMBL8498375 | 0.87 | MEN1 (0.51) | MEN1KMT2AL3MBTL1PHGDHTRPA1 | |
| SCHEMBL8525886 | 0.80 | MEN1 (0.44) | MEN1KMT2AL3MBTL1PHGDHTRPA1 | |
| SCHEMBL5669358 | 0.79 | CASP3 (0.47) | MEN1KMT2AL3MBTL1TRPA1 | |
| SCHEMBL7390779 | 0.79 | CNR2 (0.54) | TRPA1CNR2TSHR | |
| SCHEMBL7390177 | 0.78 | CNR2 (0.43) | PHGDHTRPA1CNR2TSHR | |
| SCHEMBL7387717 | 0.78 | CNR2 (0.50) | MEN1KMT2AL3MBTL1PHGDHTRPA1 | |
| SCHEMBL7387933 | 0.74 | TRPA1 (0.49) | MEN1KMT2APHGDHTRPA1CTSL | |
| SCHEMBL8496435 | 0.73 | CASP1 (0.36) | MEN1KMT2AL3MBTL1CNR2KDM4E | |
| SCHEMBL7390761 | 0.73 | KDM4E (0.42) | L3MBTL1CNR2KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877197-A | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases | CONATUS PHARMACEUTICALS, INC. | 1999-03-02 | — | — | US | disclosed |