Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4653932 | 0.74 | NPSR1 (0.46) | HDAC4HDAC2HDAC8HDAC6NPSR1 | |
| SCHEMBL27968613 | 0.73 | LMNA (0.42) | LMNACES2CES1MAPK1NPSR1 | |
| SCHEMBL14490188 | 0.73 | HDAC2 (0.50) | LMNAMAPK1HDAC4HDAC2HDAC8 | |
| SCHEMBL5988213 | 0.72 | LMNA (0.49) | LMNACES2CES1MAPK1ALDH1A1 | |
| SCHEMBL8067021 | 0.72 | ALDH1A1 (0.52) | LMNACES2CES1NPSR1ALDH1A1 | |
| SCHEMBL810175 | 0.72 | HDAC4 (0.48) | LMNAHDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL8526006 | 0.71 | CES2 (0.52) | LMNACES2CES1NPSR1ALDH1A1 | |
| SCHEMBL4212578 | 0.71 | HDAC2 (0.52) | LMNAMAPK1HDAC4HDAC2HDAC8 | |
| SCHEMBL18077380 | 0.70 | CES2 (0.52) | CES2CES1HDAC4HDAC2HDAC8 | |
| SCHEMBL570578 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999059988-A1 | NEW PROCESS | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |