Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8503404 | 0.94 | POLB (0.56) | POLBALDH1A1MAPTLMNAHPGD | |
| Benzenesulfonamide SCHEMBL8526469 | 0.83 | CA1 (0.47) | ALDH1A1HTTCA12CA1CA2 | |
| Benzenesulfonamide SCHEMBL8526332 | 0.83 | CA12 (0.47) | POLBALDH1A1LMNACA12CA1 | |
| Benzenesulfonamide SCHEMBL8526038 | 0.82 | PTGES2 (0.48) | CA12CA1CA2CA9FFAR4 | |
| SCHEMBL8502466 | 0.82 | CYP2C9 (0.53) | POLBALDH1A1KEAP1CA12CA1 | |
| SCHEMBL8504989 | 0.81 | CYP2C9 (0.53) | POLBALDH1A1MAPTLMNAHPGD | |
| SCHEMBL8504469 | 0.78 | TSHR (0.48) | ALDH1A1MAPTL3MBTL1KEAP1CYP2C9 | |
| SCHEMBL8506063 | 0.78 | CYP2C9 (0.51) | ALDH1A1HPGDHTTKEAP1CYP2C9 | |
| SCHEMBL8502313 | 0.78 | ALDH1A1 (0.49) | POLBALDH1A1LMNAHPGDL3MBTL1 | |
| Benzenesulfonamide SCHEMBL8525170 | 0.77 | PTGS1 (0.44) | ALDH1A1LMNAHPGDHTTCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946507-A1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998025896-A1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-06-18 | — | — | WO | disclosed |