Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.46 |
| ▸ | OXTR | P30559 | 3/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8506143 | 0.94 | PTGS2 (0.50) | PTGES2PTGS2OXTRAVPR1AHSD11B1 | |
| Benzenesulfonamide SCHEMBL8526332 | 0.84 | CA12 (0.47) | CA1CA2CA12CA9 | |
| Benzenesulfonamide SCHEMBL8526469 | 0.82 | CA1 (0.47) | PTGES2PTGS2CA1CA2CA12 | |
| Benzenesulfonamide SCHEMBL8526101 | 0.82 | POLB (0.51) | PTGS2CA1CA2CA12CA9 | |
| Benzenesulfonamide SCHEMBL8525970 | 0.81 | PTGES2 (0.50) | PTGES2PTGS2OXTRAVPR1ACA1 | |
| SCHEMBL8502466 | 0.81 | CYP2C9 (0.53) | PTGS2CA1CA2CA12CA9 | |
| SCHEMBL8504469 | 0.80 | TSHR (0.48) | PTGS2OXTRFFAR4 | |
| SCHEMBL8504989 | 0.80 | CYP2C9 (0.53) | PTGS2CA1CA2CA12CA9 | |
| Benzenesulfonamide SCHEMBL8525170 | 0.79 | PTGS1 (0.44) | PTGS2CA1CA2CA12CA9 | |
| SCHEMBL8502313 | 0.77 | ALDH1A1 (0.49) | OXTRAVPR1AFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946507-A1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998025896-A1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-06-18 | — | — | WO | disclosed |