Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 5/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8505677 | 0.94 | ALDH1A1 (0.41) | PTGS2FFAR4ALDH1A1GAAALOX15 | |
| SCHEMBL8505563 | 0.84 | PTGS2 (0.50) | PTGS2FFAR4ALDH1A1KMT2APKM | |
| SCHEMBL8524922 | 0.81 | ALDH1A1 (0.46) | PTGS1PTGS2CA12CA9ALDH1A1 | |
| SCHEMBL8502313 | 0.80 | ALDH1A1 (0.49) | FFAR4ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL8505150 | 0.80 | ALDH1A1 (0.47) | PTGS1PTGS2CA12CA9ALDH1A1 | |
| Benzenesulfonamide SCHEMBL8526038 | 0.79 | PTGES2 (0.48) | PTGS1PTGS2CA2CA12CA1 | |
| Benzenesulfonamide SCHEMBL8526469 | 0.77 | CA1 (0.47) | PTGS2CA2CA12CA1CA9 | |
| Benzenesulfonamide SCHEMBL8526101 | 0.77 | POLB (0.51) | PTGS1PTGS2CA2CA12CA1 | |
| SCHEMBL8505452 | 0.77 | HPGD (0.46) | PTGS1PTGS2CA12CA9FFAR4 | |
| SCHEMBL8504469 | 0.77 | TSHR (0.48) | PTGS2FFAR4ALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946507-A1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998025896-A1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-06-18 | — | — | WO | disclosed |