SCHEMBL8526227

SCHEMBL8526227

O=C(O)CC/C(=N/O)C1(C(F)(F)F)C=CC(c2ccccc2)C=C1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 1/20 0.32
PDK2 Q15119 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8525874 0.87 NR4A2 (0.32) NR4A2
SCHEMBL6843332 0.81 NR4A2 (0.33) NR4A2
SCHEMBL8663987 0.81 NR4A2 (0.33) NR4A2
SCHEMBL6709305 0.78 EDNRA (0.34)
SCHEMBL8525557 0.78 DHFR (0.31) NR4A2
SCHEMBL3539241 0.75 APEX1 (0.37) NR4A2PDK2
SCHEMBL8501778 0.74 NR4A2 (0.34) NR4A2
SCHEMBL8501943 0.70 CYP1A2 (0.32)
SCHEMBL8499414 0.69 MAPT (0.32) NR4A2
SCHEMBL11761413 0.69 NR4A2 (0.37) NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0927156-A1 BIPHENYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES WARNER-LAMBERT COMPANY (US) 1999-07-07 EP disclosed
WO-1998009940-A1 BIPHENYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES WARNER-LAMBERT COMPANY (US) 1998-03-12 WO disclosed