Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | USP5 | P45974 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6843332 | 0.83 | NR4A2 (0.33) | NR4A2ALDH1A1GAACYP2C19KEAP1 | |
| SCHEMBL8502411 | 0.82 | NR4A2 (0.37) | NR4A2ALDH1A1GAACYP2C19KEAP1 | |
| SCHEMBL8526227 | 0.81 | NR4A2 (0.32) | NR4A2 | |
| SCHEMBL8525874 | 0.81 | NR4A2 (0.32) | NR4A2CYP2C19HIF1A | |
| SCHEMBL8525557 | 0.80 | DHFR (0.31) | NR4A2 | |
| SCHEMBL8499414 | 0.71 | MAPT (0.32) | NR4A2ALDH1A1CYP2C19FFAR1LMNA | |
| SCHEMBL8501573 | 0.71 | NR4A2 (0.37) | NR4A2ALDH1A1GAACYP2C19KEAP1 | |
| SCHEMBL11761413 | 0.71 | NR4A2 (0.37) | NR4A2ALDH1A1GAACYP2C19KEAP1 | |
| SCHEMBL8501906 | 0.68 | NR4A2 (0.34) | NR4A2ALDH1A1GAACYP2C19KEAP1 | |
| SCHEMBL8501778 | 0.68 | NR4A2 (0.34) | NR4A2ALDH1A1GAACYP2C19KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927156-A1 | BIPHENYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998009940-A1 | BIPHENYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1998-03-12 | — | — | WO | disclosed |