Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.30 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6843332 | 0.84 | NR4A2 (0.33) | MAPTLMNAALDH1A1CYP2C19FFAR1 | |
| SCHEMBL8525874 | 0.72 | NR4A2 (0.32) | CYP2C19HIF1ANR4A2 | |
| SCHEMBL3583056 | 0.71 | GRM1 (0.35) | MAPTLMNAALDH1A1MAPK1CYP2C19 | |
| SCHEMBL8663987 | 0.71 | NR4A2 (0.33) | LMNAALDH1A1CYP2C19FFAR1CYP1A2 | |
| SCHEMBL8525557 | 0.71 | DHFR (0.31) | NR4A2 | |
| SCHEMBL8501573 | 0.70 | NR4A2 (0.37) | LMNAALDH1A1MAPK1CYP2C19FFAR1 | |
| SCHEMBL8526227 | 0.69 | NR4A2 (0.32) | NR4A2 | |
| SCHEMBL8499418 | 0.68 | PTGES (0.34) | MAPTLMNAPPARAALDH1A1MAPK1 | |
| SCHEMBL8501943 | 0.68 | CYP1A2 (0.32) | CYP2C19CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11761413 | 0.67 | NR4A2 (0.37) | MAPTLMNAALDH1A1MAPK1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927156-A1 | BIPHENYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998009940-A1 | BIPHENYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1998-03-12 | — | — | WO | disclosed |