Water

Water

SCHEMBL8526797

CC[N+](CC)(CC)Cc1ccc(OC)cc1.[OH-]

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 5/20 0.48
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
AGXT P21549 2/20 0.45
LTA4H P09960 1/20 0.45
TAAR1 Q96RJ0 1/20 0.45
ALDH1A1 P00352 1/20 0.44
TP53 P04637 1/20 0.44
CYP3A4 P08684 1/20 0.44
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
ALOX12 P18054 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CHRNB4 P30926 1/20 0.44
CHRNA3 P32297 1/20 0.44
CHRNA7 P36544 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8527468 0.96 IDO1 (0.48) IDO1CA12CA1CA2CA7
SCHEMBL4795994 0.82 TSHR (0.41) ALDH1A1ALOX15TSHRCHRNB4CHRNA3
SCHEMBL5675685 0.81 IDO1 (0.50) IDO1CA12CA1CA2CA7
Hydrochloric Acid SCHEMBL4803008 0.79 KDM4E (0.44) ALDH1A1TP53TSHRSMN1; SMN2CHRNB4
Hydrochloric Acid SCHEMBL10527448 0.79 IDO1 (0.48) IDO1CA12CA1CA2CA7
Water SCHEMBL8529232 0.79 LTA4H (0.50) LTA4HTSHRCHRNB4CHRNA3CHRNA7
SCHEMBL5679280 0.79 IDO1 (0.44) IDO1CA12CA1CA2CA7
Water SCHEMBL9858178 0.76 IDO1 (0.42) IDO1AGXTTAAR1ALDH1A1TSHR
SCHEMBL16187145 0.76 IDO1 (0.54) IDO1CA12CA1CA2CA7
SCHEMBL15504886 0.75 TP53 (0.43) IDO1CA2TAAR1ALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0609455-B1 PROCESS FOR PRODUCING CRESOLS SUMITOMO CHEMICAL CO (JP) 1998-03-11 EP disclosed
US-5600026-A PREVENTING THE FORMATION OF FORMALDEHYDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-02-04 US disclosed
EP-0609455-A1 PROCESS FOR PRODUCING CRESOLS SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1994-08-10 EP disclosed