SCHEMBL8527035

SCHEMBL8527035

CC(C)(C)c1ccc(C(=O)Cl)cc1C(=O)Cl

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 3/20 0.36
HSP90AB1 P08238 3/20 0.36
ESRRA P11474 2/20 0.35
RARB P10826 4/20 0.35
RARG P13631 4/20 0.35
RARA P10276 3/20 0.35
ALDH1A1 P00352 2/20 0.33
TSHR P16473 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
HDAC1 Q13547 1/20 0.33
ACE2 Q9BYF1 1/20 0.33
POLB P06746 1/20 0.33
RXRA P19793 1/20 0.33
RXRB P28702 1/20 0.33
RXRG P48443 1/20 0.33
ALOX5 P09917 1/20 0.33
PTGS1 P23219 1/20 0.33
PTGS2 P35354 1/20 0.33
GLRA3 O75311 1/20 0.33
GLRB P48167 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8151708 0.81 CES2 (0.47) ALDH1A1HDAC1POLB
SCHEMBL4684406 0.81 HSP90AA1 (0.36) HSP90AA1HSP90AB1ESRRARARBRARG
SCHEMBL4682582 0.81 ESRRA (0.41) HSP90AA1HSP90AB1ESRRAALDH1A1TSHR
SCHEMBL2154079 0.80 HSP90AA1 (0.41) HSP90AA1HSP90AB1ESRRARARBRARG
SCHEMBL1707584 0.79 NOTUM (0.46) HSP90AA1HSP90AB1ESRRARARBRARG
SCHEMBL2154020 0.79 ALDH1A1 (0.40) ALDH1A1TDP1POLBALOX5PTGS1
SCHEMBL5211234 0.78 HSP90AA1 (0.41) HSP90AA1HSP90AB1ESRRARARBRARG
SCHEMBL28059045 0.77 HSP90AA1 (0.39) HSP90AA1HSP90AB1ESRRARARBRARG
SCHEMBL15505390 0.77 TSHR (0.39) HSP90AA1HSP90AB1ESRRARARBRARG
SCHEMBL9717099 0.77 HSP90AA1 (0.58) HSP90AA1HSP90AB1ESRRARARBRARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5073176-A Permselective E. I. DU PONT DE NEMOURS AND COMPANY (US) 1991-12-17 US claimed
US-9882136-B2 Organic electroluminescent device HODOGAYA CHEMICAL CO., LTD. (JP) 2018-01-30 US disclosed
EP-2858458-B1 ORGANIC ELECTROLUMINESCENT ELEMENT HODOGAYA CHEMICAL CO LTD (JP) 2017-05-31 EP disclosed
CN-104380842-B Organic electroluminescent device 保土谷化学工业株式会社 2016-08-24 CN disclosed
US-20150287920-A1 ORGANIC ELECTROLUMINESCENT DEVICE HODOGAYA CHEMICAL CO., LTD. (JP) 2015-10-08 US disclosed
EP-2858458-A1 ORGANIC ELECTROLUMINESCENT ELEMENT Hodogaya Chemical Co., Ltd. (JP) 2015-04-08 EP disclosed
EP-0474227-B2 Functionalized peroxides for polymerization reactions ATOCHEM NORTH AMERICA ELF (US) 1998-06-10 EP disclosed
US-5723562-A BLOCK, GRAFT, AND CONDENSATION POLYMERIZATION; ESTERIFICATION, AMIDATION, ETHERIFICATION, CARBAMYLATION ELF ATOCHEM NORTH AMERICA, INC. (US) 1998-03-03 US disclosed
US-5710213-A POLYMERIZING AN UNSATURATED MONOMER OR GRAFTING AN UNSATURATED POLYMER ELF ATOCHEM NORTH AMERICA, INC. (US) 1998-01-20 US disclosed
US-5710210-A Process for polymer reactions with functionalized peroxides ELF ATOCHEM NORTH AMERICA, INC. (US) 1998-01-20 US disclosed
US-5612439-A REACTING WITH MONOMERS TO FORM POLYCARBONATES, POLYESTERS, POLYAMIDES, POLYUREAS, POLYIMIDES, POLYETHERS, AND POLYURETHANES; CURING, CROSSLINKING ELF ATOCHEM NORTH AMERICA, INC. (US) 1997-03-18 US disclosed
US-5543553-A CROSSLINKING, GRAFTING AND CURING AGENTS FOR CONDENSATIONPOLYMERS ELF ATOCHEM NORTH AMERICA, INC. (US) 1996-08-06 US disclosed
US-5536790-A MOLECULAR WEIGHT CONTROL FOR POLYMERS USING PEROXY COMPOUNDS ELF ATOCHEM NORTH AMERICA, INC. (US) 1996-07-16 US disclosed
US-5534596-A CATALYSTS FOR ADDITION POLYMERIZATION, GRAFT POLYMERIZATION, CURING OF UNSATURATED POLYESTERS ELF ATOCHEM NORTH AMERICA, INC. (US) 1996-07-09 US disclosed
US-5466855-A Functionalized peroxides for polymerization reactions ELF ATOCHEM NORTH AMERICA, INC. (US) 1995-11-14 US disclosed
US-5319130-A Monomers for condensation polymers; polyepoxides; addition polymerization initiators; compatibilizers of blends ELF ATOCHEM NORTH AMERICA, INC. (US) 1994-06-07 US disclosed
EP-0474227-A1 Functionalized peroxides for polymerization reactions ELF ATOCHEM NORTH AMERICA, INC. (US) 1992-03-11 EP disclosed
EP-0472819-A2 Polymeric peroxides derived from hydroxy-hydroperoxides and dihydroxy-dialkyl peroxides and their use ELF ATOCHEM NORTH AMERICA, INC. (US) 1992-03-04 EP disclosed
US-5073176-A Permselective E. I. DU PONT DE NEMOURS AND COMPANY (US) 1991-12-17 US disclosed
US-5039754-A Block copolymer;compatibilizing polymer blends and alloy ATOCHEM NORTH AMERICA, INC. (US) 1991-08-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150287920-A1 ORGANIC ELECTROLUMINESCENT DEVICE CDH1, STRA6, SLC39A7 HSP90AA1 2864/4885HSP90AB1 3413/4885ESRRA 1180/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.