Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LPO | P22079 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8585350 | 0.89 | MEN1 (0.45) | ALDH1A1KMT2AMEN1MAPTNPSR1 | |
| SCHEMBL8526760 | 0.73 | PKM (0.36) | MAPK14KMT2AMEN1LPONPSR1 | |
| SCHEMBL8527238 | 0.73 | LPO (0.36) | ALDH1A1KMT2AMEN1MAPTLPO | |
| SCHEMBL8526952 | 0.71 | HSD17B10 (0.38) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8584396 | 0.69 | FAAH (0.42) | ALDH1A1KDM4EMAPTLPO | |
| SCHEMBL8584050 | 0.69 | KMT2A (0.40) | ALDH1A1KMT2AMEN1LPO | |
| SCHEMBL23505897 | 0.67 | AOC3 (0.42) | ALDH1A1AOC3MAPTSMN1; SMN2 | |
| SCHEMBL6097903 | 0.67 | ALDH1A1 (0.39) | ALDH1A1KDM4EMAPK14KMT2AMEN1 | |
| SCHEMBL2297694 | 0.66 | LPO (0.40) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL8527399 | 0.63 | KMT2A (0.43) | ALDH1A1KDM4EKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885197-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | EP | claimed |
| US-5807864-A | INCREASING HIGH DENSITY LIPOPROTEIN LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-15 | — | — | US | claimed |
| WO-1997032855-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-12 | — | — | WO | claimed |
| US-5807864-A | INCREASING HIGH DENSITY LIPOPROTEIN LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-15 | — | — | US | disclosed |