Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 7/20 | 0.45 |
| ▸ | GAA | P10253 | 7/20 | 0.45 |
| ▸ | SI | P14410 | 7/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 7/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL853227 | 0.90 | MGAM (0.44) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL6162618 | 0.87 | MGAM (0.45) | MGAMGAASIMGAM2 | |
| SCHEMBL6165742 | 0.86 | MGAM (0.44) | MGAMGAASIMGAM2 | |
| SCHEMBL852769 | 0.85 | LTA4H (0.41) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL853940 | 0.83 | GAA (0.49) | MGAMGAASIMGAM2CYP2C9 | |
| SCHEMBL7364903 | 0.82 | MGAM (0.44) | MGAMGAASIMGAM2PLA2G2A | |
| SCHEMBL853781 | 0.82 | ITGB3 (0.51) | MTNR1AMTNR1BTRPM8 | |
| Hydrochloric Acid SCHEMBL6696707 | 0.82 | MGAM (0.43) | MGAMGAASIMGAM2PLA2G2A | |
| SCHEMBL6164752 | 0.81 | GAA (0.46) | MGAMGAASIMGAM2POLB | |
| SCHEMBL6693172 | 0.81 | GABRA1 (0.58) | MGAMGAASIMGAM2THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425010-B8 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | JANSSEN PHARMACEUTICALS INC (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-1425010-A4 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | ORTHO MCNEIL PHARM INC (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1425010-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2002060438-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2002-08-08 | — | — | WO | disclosed |