Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 18/20 | 0.78 |
| ▸ | ADRB1 known ✓ | P08588 | 6/20 | 0.78 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.83 |
| ▸ | DRD2 | P14416 | 4/20 | 0.78 |
| ▸ | PDE4A | P27815 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8528403 | 0.94 | ABCB11 (0.93) | ABCB11ADRB2ADRB1DRD2PDE4A | |
| Hydrochloric Acid SCHEMBL8527365 | 0.94 | ABCB11 (0.92) | ABCB11ADRB2ADRB1DRD2PDE4A | |
| Hexanoate SCHEMBL8532003 | 0.88 | ABCB11 (0.78) | ABCB11ADRB2ADRB1DRD2PDE4A | |
| Sibenadet SCHEMBL48983 | 0.88 | ADRB2 (1.00) | ABCB11ADRB2ADRB1DRD2PDE4A | |
| Sibenadet SCHEMBL30438496 | 0.88 | ADRB2 (1.00) | ABCB11ADRB2ADRB1DRD2PDE4A | |
| Sibenadet SCHEMBL249498 | 0.87 | ADRB2 (0.98) | ABCB11ADRB2ADRB1DRD2PDE4A | |
| SCHEMBL8527705 | 0.87 | ABCB11 (0.69) | ABCB11ADRB2ADRB1DRD2PDE4A | |
| SCHEMBL8531866 | 0.86 | ABCB11 (0.78) | ABCB11ADRB2ADRB1DRD2PDE4A | |
| Sibenadet SCHEMBL678828 | 0.86 | ADRB2 (0.97) | ABCB11ADRB2ADRB1DRD2PDE4A | |
| Carboxynaphthol SCHEMBL8533680 | 0.85 | ABCB11 (0.74) | ABCB11ADRB2ADRB1DRD2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649418-B1 | 7-(2-AMINOETHYL)-BENZOTHIAZOLONES | ASTRA PHARMA PROD (GB) | 1998-10-28 | — | — | EP | disclosed |
| US-5648370-A | 7-(2-aminoethyl) benzothiazolones | ASTRA PHARMACEUTICALS LIMITED (GB) | 1997-07-15 | — | — | US | disclosed |