Sibenadet

Sibenadet

SCHEMBL30438496

O=c1[nH]c2c(O)ccc(CCNCCS(=O)(=O)CCCOCCc3ccccc3)c2s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 18/20 1.00
ADRB1 P08588 4/20 1.00
DRD2 P14416 3/20 1.00
PDE4A P27815 1/20 1.00
ABCB11 O95342 2/20 0.93

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sibenadet SCHEMBL48983 1.00 ADRB2 (1.00) ADRB2ADRB1DRD2PDE4AABCB11
Sibenadet SCHEMBL249498 0.99 ADRB2 (0.98) ADRB2ADRB1DRD2PDE4AABCB11
Sibenadet SCHEMBL678828 0.98 ADRB2 (0.97) ADRB2ADRB1DRD2PDE4AABCB11
SCHEMBL8528403 0.93 ABCB11 (0.93) ADRB2ADRB1DRD2PDE4AABCB11
Hydrochloric Acid SCHEMBL8527365 0.92 ABCB11 (0.92) ADRB2ADRB1DRD2PDE4AABCB11
SCHEMBL8528272 0.91 ADRB2 (0.84) ADRB2ADRB1DRD2PDE4AABCB11
Hydrochloric Acid SCHEMBL8533852 0.91 ADRB2 (0.82) ADRB2ADRB1DRD2PDE4AABCB11
SCHEMBL7829477 0.90 ADRB2 (0.81) ADRB2ADRB1DRD2PDE4AABCB11
Hydrochloric Acid SCHEMBL7842790 0.89 ADRB2 (0.80) ADRB2ADRB1DRD2PDE4AABCB11
SCHEMBL5386480 0.89 ADRB2 (0.80) ADRB2ADRB1DRD2PDE4AABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12629379-B2 Pharmaceutical composition for preventing, suppressing, or treating symptom associated with allergic reaction NIPPON CHEMIPHAR CO., LTD. (JP) 2026-05-19 US disclosed
US-20260000678-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOM ASSOCIATED WITH PSEUDO-ALLERGIC REACTION TAKASAKI UNIV OF HEALTH AND WELFARE (JP) 2026-01-01 US disclosed
US-12233071-B2 Medicament for treating cough NIPPON CHEMIPHAR CO., LTD. (JP) 2025-02-25 US disclosed
EP-4501357-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR SUPPRESSING OR TREATING SYMPTOMS ACCOMPANYING PSEUDO-ALLERGIC REACTIONS Takasaki University of Health and Welfare (JP) 2025-02-05 EP disclosed
WO-2023190826-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR SUPPRESSING OR TREATING SYMPTOMS ACCOMPANYING PSEUDO-ALLERGIC REACTIONS 学校法人 高崎健康福祉大学 2023-10-05 WO disclosed
US-20230277552-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOM ASSOCIATED WITH ALLERGIC REACTION NIPPON CHEMIPHAR CO., LTD. (JP) 2023-09-07 US disclosed
US-20230248738-A1 MEDICAMENT FOR TREATING COUGH NIPPON CHEMIPHAR CO., LTD (JP) 2023-08-10 US disclosed
EP-4190356-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOMS ASSOCIATED WITH ALLERGIC REACTION Nippon Chemiphar Co., Ltd. (JP) 2023-06-07 EP disclosed
US-11666582-B2 Medicament for treating cough NIPPON CHEMIPHAR CO., LTD. (JP) 2023-06-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12233071-B2 Medicament for treating cough P2RX4, P2RX3, P2RX5 ADRB2 74/4885ADRB1 72/4885DRD2 2955/4885
US-11666582-B2 Medicament for treating cough P2RX4, P2RX3, P2RX5 ADRB2 74/4885ADRB1 72/4885DRD2 2955/4885
US-12629379-B2 Pharmaceutical composition for preventing, suppressing, or treating symptom associated with allergic reaction HRH2, HRH4, HRH1 ADRB2 39/4885ADRB1 43/4885DRD2 3194/4885
US-20260000678-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOM ASSOCIATED WITH PSEUDO-ALLERGIC REACTION TRPV1, TRPV4, TRPV5 ADRB2 537/4885ADRB1 503/4885DRD2 2753/4885
US-20230277552-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOM ASSOCIATED WITH ALLERGIC REACTION P2RX5, P2RX3, P2RX2 ADRB2 113/4885ADRB1 96/4885DRD2 1617/4885
US-20230248738-A1 MEDICAMENT FOR TREATING COUGH P2RX4, P2RX3, P2RX5 ADRB2 74/4885ADRB1 72/4885DRD2 2955/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.