SCHEMBL8527895

SCHEMBL8527895

CO[C]c1cccc2ccccc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHAT P28329 1/20 0.43
ALDH1A1 P00352 5/20 0.43
CYP2A6 P11509 4/20 0.43
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
MAPT P10636 1/20 0.41
TSHR P16473 3/20 0.40
HSD17B10 Q99714 3/20 0.40
TDP1 Q9NUW8 2/20 0.40
GRM5 P41594 1/20 0.40
CYP1A2 P05177 5/20 0.38
CYP3A4 P08684 2/20 0.38
HPGD P15428 2/20 0.38
KEAP1 Q14145 1/20 0.38
HPRT1 P00492 1/20 0.37
RAB9A P51151 1/20 0.37
KDM4E B2RXH2 1/20 0.36
MAPK1 P28482 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CYP2D6 P10635 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10672190 1.00 CHAT (0.43) CHATALDH1A1CYP2A6CA1CA2
SCHEMBL2789100 0.79 CHAT (0.49) CHATALDH1A1CYP2A6CA1CA2
SCHEMBL1663806 0.75 ALDH1A1 (0.48) CHATALDH1A1CYP2A6CA1CA2
SCHEMBL2776015 0.74 CHAT (0.60) CHATALDH1A1CYP2A6CA1CA2
SCHEMBL29661843 0.74 CHAT (0.60) CHATALDH1A1CYP2A6CA1CA2
SCHEMBL814962 0.74 HPRT1 (0.52) CHATALDH1A1CYP2A6CA1CA2
SCHEMBL1141298 0.74 HPRT1 (0.52) CHATALDH1A1CYP2A6CA1CA2
SCHEMBL10804459 0.74 HPRT1 (0.52) CHATALDH1A1CYP2A6CA1CA2
SCHEMBL28371725 0.72 GRM5 (0.50) CHATALDH1A1CA1CA2MAPT
SCHEMBL6364668 0.72 CHAT (0.58) CHATALDH1A1CYP2A6CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0938479-A1 QUATERNARY NITROGEN HETEROCYCLES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS PESTICIDES Hoechst Schering AgrEvo GmbH (DE) 1999-09-01 EP disclosed
WO-1998022445-A1 QUATERNARY NITROGEN HETEROCYCLES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS PESTICIDES HOECHST SCHERING AGREVO GMBH (DE) 1998-05-28 WO disclosed
US-4735959-A HYPOGLYCEMIC AGENTS DR. KARL THOMAE GMBH (DE) 1988-04-05 US disclosed