Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.48 |
| ▸ | CHAT | P28329 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1611988 | 0.81 | CHAT (0.53) | ALDH1A1CYP2A6CHATCA1CA2 | |
| SCHEMBL814962 | 0.79 | HPRT1 (0.52) | ALDH1A1CYP2A6CHATCA1CA2 | |
| SCHEMBL1141298 | 0.79 | HPRT1 (0.52) | ALDH1A1CYP2A6CHATCA1CA2 | |
| SCHEMBL29661843 | 0.79 | CHAT (0.60) | ALDH1A1CYP2A6CHATCA1CA2 | |
| SCHEMBL2776015 | 0.79 | CHAT (0.60) | ALDH1A1CYP2A6CHATCA1CA2 | |
| SCHEMBL10804459 | 0.79 | HPRT1 (0.52) | ALDH1A1CYP2A6CHATCA1CA2 | |
| SCHEMBL6364668 | 0.77 | CHAT (0.58) | ALDH1A1CYP2A6CHATCA1CA2 | |
| SCHEMBL28113790 | 0.76 | CA1 (0.44) | ALDH1A1CYP2A6CHATCA1CA2 | |
| SCHEMBL5865111 | 0.75 | CA1 (0.47) | ALDH1A1CYP2A6CHATCA1CA2 | |
| SCHEMBL507946 | 0.75 | CA1 (0.47) | ALDH1A1CYP2A6CHATCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5393760-A | Cardiovascular disorders, antitumor agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | claimed |
| EP-0468231-B1 | Guanidins | HOFFMANN LA ROCHE (CH) | 1994-09-21 | — | — | EP | claimed |
| US-20200308109-A1 | FLUORENE COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2020-10-01 | — | — | US | disclosed |
| EP-2565210-B1 | RESIN FINE POWDER CONSISTING OF 4-METHYL-1-PENTENE POLYMER, COMPOSITION CONTAINING SAME, AND PROCESS FOR PRODUCTION THEREOF | MITSUI CHEMICALS INC (JP) | 2019-11-06 | — | — | EP | disclosed |
| US-10457786-B2 | Biaxially-stretched film and ethylene polymer composition | PRIME POLYMER CO., LTD. (JP) | 2019-10-29 | — | — | US | disclosed |
| US-20190177271-A1 | FLUORENE COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2019-06-13 | — | — | US | disclosed |
| US-9902847-B2 | 4-methyl-1-pentene (co)polymer composition, and film and hollow molded product composed of the composition | MITSUI CHEMICALS, INC. (JP) | 2018-02-27 | — | — | US | disclosed |
| EP-2960270-B1 | BIAXIALLY STRETCHED FILM, AND ETHYLENE-TYPE POLYMER COMPOSITION | PRIME POLYMER CO LTD (JP) | 2017-12-20 | — | — | EP | disclosed |
| EP-2799486-B1 | ETHYLENE-BASED POLYMER COMPOSITION, AND MOLDED BODY OBTAINED FROM SAME | MITSUI CHEMICALS INC (JP) | 2017-08-23 | — | — | EP | disclosed |
| US-9657117-B2 | 4-methyl-1-pentene polymer, resin composition containing 4-methyl-1-pentene polymer, masterbatch thereof, and formed product thereof | MITSUI CHEMICALS, INC. (JP) | 2017-05-23 | — | — | US | disclosed |
| EP-2799488-B1 | 4-METHYL-1-PENTENE (CO)POLYMER COMPOSITION, AND FILM AND HOLLOW MOLDED BODY, EACH OF WHICH IS FORMED FROM 4-METHYL-1-PENTENE (CO)POLYMER COMPOSITION | MITSUI CHEMICALS INC (JP) | 2016-07-20 | — | — | EP | disclosed |
| EP-1302508-A1 | AUTOMOTIVE PART MADE OF POLYPROPYLENE RESIN COMPOSITION | Mitsui Chemicals, Inc. (JP) | 2003-04-16 | — | — | EP | disclosed |
| EP-1138687-A1 | METALLOCENE COMPOUND, PROCESS FOR PRODUCING METALLOCENE COMPOUND, OLEFIN POLYMERIZATION CATALYST, PROCESS FOR PRODUCING POLYOLEFIN, AND POLYOLEFIN | Mitsui Chemicals, Inc. (JP) | 2001-10-04 | — | — | EP | disclosed |
| US-5763436-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| US-5595999-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5583133-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-12-10 | — | — | US | disclosed |
| US-5532232-A | INHIBIT THROMBIN INDUCED PLATELET AGGREGATION; FIBRINOGEN ANTICOAGULANTS IN BLOOD | HOFFMANN-LA ROCHE INC. (US) | 1996-07-02 | — | — | US | disclosed |
| US-5393760-A | Cardiovascular disorders, antitumor agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |
| US-5260307-A | Inhibit thrombin-induced platlet aggregation and clotting of fibrogen in plasma | HOFMANN-LA ROCHE INC. (US) | 1993-11-09 | — | — | US | disclosed |
| US-4735959-A | HYPOGLYCEMIC AGENTS | DR. KARL THOMAE GMBH (DE) | 1988-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177271-A1 | FLUORENE COMPOUND AND PHARMACEUTICAL USE THEREOF | FH, PCK2, PC | ALDH1A1 1793/4885CYP2A6 2957/4885CHAT 3807/4885 |
| US-20200308109-A1 | FLUORENE COMPOUND AND PHARMACEUTICAL USE THEREOF | FH, PCK2, PC | ALDH1A1 1793/4885CYP2A6 2957/4885CHAT 3807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.