SCHEMBL8529892

SCHEMBL8529892

COc1nc(N)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](OC(=O)C(C)(C)C)[C@@H]1O

nearest known ligand 0.52

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.52
ADORA2A P29274 3/20 0.51
ADORA3 P0DMS8 3/20 0.51
ADORA1 P30542 2/20 0.51
ADORA2B P29275 2/20 0.51
SLC29A1 Q99808 5/20 0.48
PGK1 P00558 1/20 0.47
PGK2 P07205 1/20 0.47
HINT1 P49773 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8532515 0.93 CYP2C19 (0.52) CYP2C19ADORA2AADORA3ADORA1ADORA2B
SCHEMBL8529007 0.85 SLC29A1 (0.50) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL13657986 0.84 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL2143756 0.84 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL9937290 0.84 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL1818971 0.84 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL18321891 0.84 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL18820 0.84 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL20769831 0.84 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL13575801 0.84 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5821236-A Tumor treatment with arabinofuranosyl purine derivatives GLAXO WELLCOME INC. (US) 1998-10-13 US disclosed
US-5747472-A ANTICARCINOGENIC AGENTS AND ANTITUMOR AGENTS GLAXO WELLCOME INC. (US) 1998-05-05 US disclosed
US-5492897-A ANTITUMOR AGENTS, AUTOIMMUNE DISEASES BURROUGHS WELLCOME CO. (141) (US) 1996-02-20 US disclosed
US-5424295-A Useful in treatment of varicella-zoster virus infections BURROUGHS WELLCOME CO. (US) 1995-06-13 US disclosed