Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8530683 | 0.80 | KDM1A (0.42) | HTR2AHTR2CHTR2BKDM4EKDM1A | |
| SCHEMBL7480391 | 0.79 | PRCP (0.38) | HTR2AHTR2CHTR2BKDM1A | |
| SCHEMBL8533494 | 0.79 | PRCP (0.38) | HTR2AHTR2CHTR2BKDM1A | |
| SCHEMBL6227686 | 0.78 | SLC18A3 (0.38) | HTR2BKDM4E | |
| SCHEMBL472003 | 0.78 | SLC18A3 (0.38) | HTR2BKDM4E | |
| SCHEMBL8531757 | 0.78 | KDM1A (0.37) | HTR2AHTR2CHTR2BKDM1A | |
| SCHEMBL8530406 | 0.74 | SLC6A2 (0.35) | RIPK1 | |
| SCHEMBL3503155 | 0.72 | CHRNB2 (0.53) | HCRTR2CA1 | |
| SCHEMBL433220 | 0.72 | CHRNB2 (0.53) | HCRTR2CA1 | |
| SCHEMBL29450150 | 0.72 | CHRNB2 (0.53) | HCRTR2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843966-A | Piperidine derivatives | GLAXO GROUP LIMITED (GB) | 1998-12-01 | — | — | US | disclosed |
| US-5703240-A | ANALGESICS; ANTIINFLAMMATORY AGENTS; NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS | GLAXO GROUP LIMITED (GB) | 1997-12-30 | — | — | US | disclosed |