Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531757 | 0.85 | KDM1A (0.37) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNB4 | |
| SCHEMBL8531187 | 0.83 | ABCC9 (0.34) | — | |
| SCHEMBL8533494 | 0.76 | PRCP (0.38) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8533774 | 0.76 | MAPT (0.42) | — | |
| SCHEMBL7480391 | 0.76 | PRCP (0.38) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8530249 | 0.74 | HTR2A (0.37) | RIPK1 | |
| SCHEMBL2708051 | 0.73 | L3MBTL1 (0.44) | CHRNB2CHRNA4 | |
| SCHEMBL8530281 | 0.70 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3NISCHRIPK1 | |
| SCHEMBL8530283 | 0.70 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3NISCHRIPK1 | |
| SCHEMBL8530279 | 0.70 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3NISCHRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843966-A | Piperidine derivatives | GLAXO GROUP LIMITED (GB) | 1998-12-01 | — | — | US | disclosed |
| US-5703240-A | ANALGESICS; ANTIINFLAMMATORY AGENTS; NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS | GLAXO GROUP LIMITED (GB) | 1997-12-30 | — | — | US | disclosed |