Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | AKT2 | P31751 | 2/20 | 0.43 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8590004 | 0.82 | TLK2 (0.41) | NTRK1AKT2TLK2PDPK1PDK1 | |
| SCHEMBL8529757 | 0.81 | PDPK1 (0.58) | NTRK1RETTDP1TLK2PDPK1 | |
| SCHEMBL8530485 | 0.81 | DHFR (0.42) | NTRK1TLK2PDK1CHEK1 | |
| SCHEMBL8527884 | 0.79 | AKT2 (0.58) | AKT2TLK2PDPK1PDK1 | |
| SCHEMBL8506472 | 0.77 | TDP1 (0.47) | NTRK1RETTDP1FLT3CHEK1 | |
| SCHEMBL7131127 | 0.77 | NTRK1 (0.47) | NTRK1RETTDP1FLT3LRRK2 | |
| SCHEMBL8508649 | 0.77 | RPS6KA3 (0.54) | NTRK1RETTDP1FLT3PDPK1 | |
| SCHEMBL8529758 | 0.77 | PDPK1 (0.52) | NTRK1RETTDP1FLT3PSEN1 | |
| SCHEMBL8585839 | 0.76 | TLK2 (0.49) | TLK2PDK1 | |
| SCHEMBL8530158 | 0.76 | RET (0.45) | NTRK1RETTDP1FLT3PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876365-A1 | SUBSTITUTED QUINOLYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997046551-A1 | SUBSTITUTED QUINOLYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-12-11 | — | — | WO | disclosed |