Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 11/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614775 | 0.82 | NTRK1 (0.44) | TLK2NTRK1PDK1PDPK1AKT2 | |
| SCHEMBL8527884 | 0.82 | AKT2 (0.58) | TLK2PDK1PDPK1AKT2 | |
| SCHEMBL8530485 | 0.80 | DHFR (0.42) | TLK2PAK1NTRK1PDK1CHEK1 | |
| SCHEMBL8530156 | 0.77 | PDPK1 (0.55) | NTRK1PDPK1CHEK1 | |
| SCHEMBL8585839 | 0.77 | TLK2 (0.49) | TLK2PAK1PDK1 | |
| SCHEMBL8529757 | 0.76 | PDPK1 (0.58) | TLK2NTRK1PDPK1CHEK1 | |
| SCHEMBL8529758 | 0.76 | PDPK1 (0.52) | NTRK1PDPK1CHEK1 | |
| SCHEMBL8508649 | 0.76 | RPS6KA3 (0.54) | NTRK1PDPK1CHEK1 | |
| SCHEMBL8530158 | 0.76 | RET (0.45) | NTRK1PDPK1CHEK1 | |
| SCHEMBL8301615 | 0.76 | TLK2 (0.58) | TLK2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876365-A1 | SUBSTITUTED QUINOLYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997046551-A1 | SUBSTITUTED QUINOLYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-12-11 | — | — | WO | disclosed |