Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 8/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537300 | 0.87 | KIF11 (0.46) | MAT2AKIF11PDE2ADHODHPDE4B | |
| SCHEMBL8537912 | 0.84 | MAT2A (0.59) | MAT2AKIF11DGAT1CHRM5PDE2A | |
| SCHEMBL8514278 | 0.83 | KIF11 (0.42) | MAT2AKIF11PDE2ADHODHPDE4B | |
| SCHEMBL9607469 | 0.82 | MAT2A (0.44) | MAT2A | |
| SCHEMBL8536602 | 0.74 | MAT2A (0.62) | MAT2AKIF11DGAT1SCN10AKCNH2 | |
| SCHEMBL8533063 | 0.74 | MAT2A (0.55) | MAT2AKIF11DGAT1ACP1CYP1A2 | |
| SCHEMBL8536444 | 0.73 | MAT2A (0.64) | MAT2AKIF11DGAT1SCN10AKCNH2 | |
| SCHEMBL8535564 | 0.73 | MAT2A (0.66) | MAT2ADHODHACP1CYP1A2 | |
| SCHEMBL8530848 | 0.73 | MAT2A (0.77) | MAT2AKIF11DGAT1ACP1CYP1A2 | |
| SCHEMBL8537649 | 0.72 | MAT2A (0.52) | MAT2AKIF11PDE2ADHODHPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |