Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | HTR2A | P28223 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8534940 | 0.83 | DRD2 (0.38) | DRD2HTR2A | |
| SCHEMBL8533128 | 0.78 | DRD2 (0.49) | DRD2HTR2AHRH3SIGMAR1 | |
| SCHEMBL8532322 | 0.78 | DRD2 (0.38) | DRD2HTR2AHRH3 | |
| SCHEMBL8533143 | 0.72 | DRD2 (0.40) | DRD2HTR2ASIGMAR1 | |
| SCHEMBL8199358 | 0.70 | BACE1 (0.57) | HRH3 | |
| SCHEMBL8199355 | 0.70 | BACE1 (0.57) | HRH3 | |
| SCHEMBL8199357 | 0.70 | BACE1 (0.57) | HRH3 | |
| SCHEMBL8535562 | 0.69 | DRD2 (0.38) | DRD2HTR2A | |
| SCHEMBL8236868 | 0.66 | SLC6A9 (0.51) | DRD2HTR2A | |
| SCHEMBL8198558 | 0.65 | SLC18A3 (0.46) | DRD2HTR2ATP53SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847159-A | 1- ω-(3,4-dihydro-2-naphthalenyl)alkyl!-cyclic amine derivatives, process for preparing the same, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| EP-0825180-A1 | 1-OMEGA-(3,4-DIHYDRO-2-NAPHTHALENYL)ALKYL] CYCLIC AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |