SCHEMBL8533249

SCHEMBL8533249

CCNc1ccc(C=Cc2ccc(NCC)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.47
ADRA2A P08913 4/20 0.45
ADRA2B P18089 2/20 0.45
ADRA2C P18825 2/20 0.45
LMNA P02545 1/20 0.45
APP P05067 9/20 0.45
KCNH2 Q12809 1/20 0.38
RELA Q04206 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12387901 1.00 MAPT (0.47) MAPTADRA2AADRA2BADRA2CLMNA
SCHEMBL8422585 0.91 LMNA (0.53) MAPTADRA2ALMNAAPPRELA
SCHEMBL13827339 0.89 APP (0.62) MAPTLMNAAPPRELA
SCHEMBL12387898 0.89 APP (0.56) MAPTADRA2AADRA2BADRA2CLMNA
SCHEMBL12657463 0.86 CHAT (0.52) MAPTLMNA
SCHEMBL526383 0.84 MAPT (0.58) MAPTADRA2AADRA2BADRA2CLMNA
SCHEMBL7940575 0.83 APP (0.44) MAPTADRA2AADRA2BADRA2CLMNA
SCHEMBL7940576 0.83 APP (0.44) MAPTADRA2AADRA2BADRA2CLMNA
SCHEMBL9391329 0.83 ALDH1A1 (0.48) MAPTADRA2AADRA2BADRA2CLMNA
SCHEMBL5172276 0.83 MAPT (0.45) MAPTADRA2AADRA2BADRA2CLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0708796-B1 PROCESS FOR PREPARING COMPOSITES BASED ON ORIENTED MESOGENIC THERMOSET RESINS DOW CHEMICAL CO (US) 1998-05-27 EP disclosed
EP-0708796-A1 PROCESS FOR PREPARING COMPOSITES BASED ON ORIENTED MESOGENIC THERMOSET RESINS THE DOW CHEMICAL COMPANY (US) 1996-05-01 EP disclosed
US-5424393-A Curing into liquid crystals THE DOW CHEMICAL COMPANY (US) 1995-06-13 US disclosed
WO-1995002631-A1 PROCESS FOR PREPARING COMPOSITES BASED ON ORIENTED MESOGENIC THERMOSET RESINS THE DOW CHEMICAL COMPANY (US) 1995-01-26 WO disclosed
US-5248740-A Thioepoxides, liquid crystal polymers THE DOW CHEMICAL COMPANY (US) 1993-09-28 US disclosed
US-5248360-A Saturating fiber substrates with curable thermosetting resin, arranging substrates into desired configuration, curing with application of heat and pressure THE DOW CHEMICAL COMPANY (US) 1993-09-28 US disclosed
US-5182340-A Molding materials having shorter gel time with aliphatic amine curing agents THE DOW CHEMICAL COMPANY (US) 1993-01-26 US disclosed