Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | DDO | Q99489 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5306250 | 0.86 | CYP11B1 (0.54) | PTGS2ALDH1A1KIF11MAPTNR1I3 | |
| SCHEMBL9607489 | 0.84 | HTT (0.48) | PTGS2HTTHPGDKDM4EALDH1A1 | |
| SCHEMBL9607173 | 0.82 | CYP11B1 (0.48) | HTTHPGDKDM4EALDH1A1LMNA | |
| SCHEMBL26724947 | 0.81 | KIF11 (0.47) | HTTHPGDKDM4EALDH1A1LMNA | |
| SCHEMBL21024209 | 0.81 | PDE10A (0.47) | HTTHPGDKDM4EALDH1A1LMNA | |
| SCHEMBL8533400 | 0.80 | KIF11 (0.47) | HTTHPGDKDM4EALDH1A1LMNA | |
| SCHEMBL16585681 | 0.79 | CTSV (0.57) | LMNAGAAKIF11MEN1KMT2A | |
| SCHEMBL8533957 | 0.79 | PDE10A (0.51) | HTTHPGDKDM4EALDH1A1LMNA | |
| SCHEMBL8515205 | 0.77 | SLC2A1 (0.52) | PTGS2HTTHPGDKDM4EALDH1A1 | |
| SCHEMBL8532778 | 0.77 | PTGS2 (0.46) | PTGS2HTTKDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |