Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL810175 | 0.94 | HDAC4 (0.48) | ALDH1A1HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL2774579 | 0.80 | HDAC2 (0.60) | HDAC4HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL5383447 | 0.79 | ALDH1A1 (0.49) | ALDH1A1HDAC6HDAC1MAPTLMNA | |
| SCHEMBL18077380 | 0.77 | CES2 (0.52) | HDAC4HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL492236 | 0.77 | HDAC4 (0.41) | ALDH1A1HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL9028437 | 0.76 | HDAC2 (0.59) | ALDH1A1HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL2897987 | 0.76 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1ATMTDP1SRD5A2 | |
| SCHEMBL24713177 | 0.75 | SETD7 (0.49) | ALDH1A1LMNATP53MEN1KMT2A | |
| SCHEMBL30313562 | 0.74 | CES2 (0.47) | ALDH1A1HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL18334680 | 0.74 | CES2 (0.47) | ALDH1A1HDAC4HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010110400-A1 | HETEROCYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2010-09-30 | — | — | WO | disclosed |
| CN-1216522-A | Therapeutic agent for diabetes | JAPAN TOBACCO INC (JP) | 1999-05-12 | — | — | CN | disclosed |
| EP-0885869-A1 | THERAPEUTIC AGENT FOR DIABETES | Japan Tobacco Inc. (JP) | 1998-12-23 | — | — | EP | disclosed |