Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 12/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ILK | Q13418 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9098983 | 0.86 | PTGS2 (0.58) | MALT1NFKB1NFKB2RELAPTGS2 | |
| SCHEMBL9105407 | 0.77 | PTGS2 (0.56) | MALT1PTGS2PTGS1EPHX2CHRNA7 | |
| SCHEMBL9100132 | 0.76 | PTGS2 (0.56) | MALT1PTGS2PTGS1EPHX2CHRNA7 | |
| SCHEMBL8537811 | 0.75 | CHRNA7 (0.57) | MALT1NFKB1NFKB2RELAPTGS2 | |
| SCHEMBL9105969 | 0.72 | ILK (0.67) | PTGS2PTGS1EPHX2CHRNA7ILK | |
| SCHEMBL8794524 | 0.71 | PTGS1 (0.64) | MALT1NFKB1NFKB2RELAPTGS2 | |
| SCHEMBL8536452 | 0.70 | CA9 (0.57) | MALT1NFKB1NFKB2RELAPTGS2 | |
| SCHEMBL19839523 | 0.70 | ILK (0.68) | MALT1PTGS2PTGS1EPHX2CHRNA7 | |
| SCHEMBL9202586 | 0.70 | MALT1 (0.56) | MALT1NFKB1NFKB2RELAPTGS2 | |
| SCHEMBL9101594 | 0.69 | ILK (0.64) | MALT1NFKB1NFKB2RELAPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642856-A1 | INTEGRIN-LINKED KINASE INHIBITORS | The Ohio State University Research Foundation (US) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012071310-A1 | INTEGRIN-LINKED KINASE INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-05-31 | — | — | WO | disclosed |