Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
| ▸ | MALT1 | Q9UDY8 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | ILK | Q13418 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9098983 | 0.91 | PTGS2 (0.58) | PTGS2EPHX2PTGS1CHRNA7MALT1 | |
| SCHEMBL9100132 | 0.89 | PTGS2 (0.56) | PTGS2EPHX2PTGS1CHRNA7MALT1 | |
| SCHEMBL9100491 | 0.86 | ILK (0.56) | PTGS2EPHX2PTGS1CHRNA7MALT1 | |
| SCHEMBL8537811 | 0.85 | CHRNA7 (0.57) | PTGS2EPHX2PTGS1CHRNA7MALT1 | |
| SCHEMBL9105969 | 0.80 | ILK (0.67) | PTGS2EPHX2PTGS1CHRNA7MAPT | |
| SCHEMBL8536452 | 0.80 | CA9 (0.57) | PTGS2EPHX2PTGS1CHRNA7MALT1 | |
| SCHEMBL9102404 | 0.78 | ILK (0.55) | PTGS2EPHX2PTGS1CHRNA7MAPT | |
| SCHEMBL9101594 | 0.78 | ILK (0.64) | PTGS2EPHX2PTGS1CHRNA7MALT1 | |
| SCHEMBL8534003 | 0.77 | MALT1 (0.55) | PTGS2EPHX2PTGS1CHRNA7MALT1 | |
| SCHEMBL16196652 | 0.75 | PDPK1 (0.62) | PTGS2EPHX2PTGS1MALT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642856-B1 | INTEGRIN-LINKED KINASE INHIBITORS | UNIV OHIO STATE RES FOUND (US) | 2017-07-19 | — | — | EP | disclosed |
| US-8658647-B2 | Integrin-linked kinase inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2014-02-25 | — | — | US | disclosed |
| US-20120142702-A1 | INTEGRIN-LINKED KINASE INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142702-A1 | INTEGRIN-LINKED KINASE INHIBITORS | PTK2, ITGB1, ITGB2 | PTGS2 2751/4885EPHX2 3969/4885PTGS1 2318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.