Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | MALT1 | Q9UDY8 | 6/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537811 | 0.86 | CHRNA7 (0.57) | CHRNA7PTGS1PTGS2EPHX2MALT1 | |
| SCHEMBL9103432 | 0.85 | CA9 (0.72) | CA9CHRNA7PTGS1PTGS2CYP2C9 | |
| SCHEMBL9101594 | 0.81 | ILK (0.64) | CHRNA7PTGS1PTGS2EPHX2MALT1 | |
| SCHEMBL9105407 | 0.80 | PTGS2 (0.56) | CHRNA7PTGS1PTGS2EPHX2MALT1 | |
| SCHEMBL17077240 | 0.79 | PTGS1 (0.80) | PTGS1PTGS2CYP2C9PDPK1 | |
| SCHEMBL17077245 | 0.78 | ILK (0.70) | CA9CHRNA7PTGS1PTGS2EPHX2 | |
| SCHEMBL15560871 | 0.77 | RXRA (0.62) | CA9PTGS1PTGS2EPHX2CYP2C9 | |
| SCHEMBL17077244 | 0.77 | ILK (0.52) | CA9CHRNA7PTGS1PTGS2CYP2C9 | |
| SCHEMBL17077237 | 0.74 | ILK (0.62) | CA9PTGS1PTGS2EPHX2 | |
| SCHEMBL9199132 | 0.72 | CA9 (0.80) | CA9CHRNA7PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642856-B1 | INTEGRIN-LINKED KINASE INHIBITORS | UNIV OHIO STATE RES FOUND (US) | 2017-07-19 | — | — | EP | disclosed |
| US-8658647-B2 | Integrin-linked kinase inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2014-02-25 | — | — | US | disclosed |
| EP-2642856-A1 | INTEGRIN-LINKED KINASE INHIBITORS | The Ohio State University Research Foundation (US) | 2013-10-02 | — | — | EP | disclosed |
| US-20120142702-A1 | INTEGRIN-LINKED KINASE INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-06-07 | — | — | US | disclosed |
| WO-2012071310-A1 | INTEGRIN-LINKED KINASE INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142702-A1 | INTEGRIN-LINKED KINASE INHIBITORS | PTK2, ITGB1, ITGB2 | CA9 2026/4885CHRNA7 1521/4885PTGS1 2318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.