Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 13/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 13/20 | 0.47 |
| ▸ | PPARD | Q03181 | 3/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.43 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8536553 | 0.82 | DGAT1 (0.57) | DGAT1ITGB3ITGA2BPPARDCYP26A1 | |
| SCHEMBL8531874 | 0.82 | DGAT1 (0.36) | DGAT1ITGB3ITGA2BCYP26A1CYP24A1 | |
| SCHEMBL12978373 | 0.82 | DGAT1 (0.50) | DGAT1ITGB3ITGA2BCYP26A1FFAR1 | |
| SCHEMBL8534988 | 0.81 | CYP11B1 (0.41) | DGAT1CYP26A1 | |
| SCHEMBL4622497 | 0.78 | CYP26A1 (0.70) | DGAT1ITGB3ITGA2BCYP26A1CYP24A1 | |
| SCHEMBL9638064 | 0.78 | CYP19A1 (0.64) | DGAT1ITGB3ITGA2BCYP26A1CYP24A1 | |
| SCHEMBL11723357 | 0.77 | THRA (0.52) | — | |
| SCHEMBL10341531 | 0.77 | CYP26A1 (0.59) | DGAT1ITGB3ITGA2BCYP26A1 | |
| SCHEMBL29405721 | 0.77 | CYP19A1 (0.49) | DGAT1ITGB3ITGA2BCYP26A1FFAR1 | |
| SCHEMBL18321998 | 0.77 | CYP19A1 (0.49) | DGAT1ITGB3ITGA2BCYP26A1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10120632-A | — | — | None | — | — | JP | disclosed |
| US-5847159-A | 1- ω-(3,4-dihydro-2-naphthalenyl)alkyl!-cyclic amine derivatives, process for preparing the same, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| JP-H10120632-A | N-CYCLOALKYL-(OMEGA-(3,4-DIHYDRO-2NAPHTHALENYL) ALKYL)AMINE DERIVATIVE AND MEDICINE CONTAINING THE SAME | DAINIPPON PHARMACEUT CO LTD | 1998-05-12 | — | — | JP | disclosed |
| EP-0825180-A1 | 1-OMEGA-(3,4-DIHYDRO-2-NAPHTHALENYL)ALKYL] CYCLIC AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |