Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.36 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8534988 | 0.83 | CYP11B1 (0.41) | DGAT1CYP26A1TSHRCHRM2CHRM4 | |
| SCHEMBL8534684 | 0.82 | DGAT1 (0.50) | DGAT1CYP26A1CYP24A1ITGB3ITGA2B | |
| SCHEMBL8533781 | 0.75 | ROCK2 (0.38) | CYP26A1CYP24A1 | |
| SCHEMBL11723357 | 0.72 | THRA (0.52) | — | |
| SCHEMBL8535491 | 0.71 | IMPDH2 (0.40) | CYP26A1CYP24A1CYP19A1 | |
| Hydrochloric Acid SCHEMBL8531523 | 0.71 | METAP1 (0.54) | — | |
| Iodide SCHEMBL8534944 | 0.71 | CYP26A1 (0.39) | CYP26A1CYP24A1CYP19A1 | |
| SCHEMBL8531913 | 0.68 | CHRM2 (0.48) | DGAT1CYP26A1TSHRCHRM2CHRM4 | |
| SCHEMBL8532323 | 0.68 | CHRM2 (0.46) | TSHRCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL8536553 | 0.66 | DGAT1 (0.57) | DGAT1CYP26A1CYP24A1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847159-A | 1- ω-(3,4-dihydro-2-naphthalenyl)alkyl!-cyclic amine derivatives, process for preparing the same, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| EP-0825180-A1 | 1-OMEGA-(3,4-DIHYDRO-2-NAPHTHALENYL)ALKYL] CYCLIC AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |