Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.38 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | ASPH | Q12797 | 1/20 | 0.34 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8536081 | 0.70 | GABRA1 (0.40) | GPR132VKORC1LMNACYP3A4CYP2D6 | |
| SCHEMBL8534845 | 0.70 | CHRM2 (0.37) | GPR132VKORC1LMNACHRM2CHRM1 | |
| SCHEMBL7373615 | 0.66 | GPR132 (0.39) | GPR132LMNANAMPTALDH1A1PKM | |
| SCHEMBL7457650 | 0.65 | GPR132 (0.40) | GPR132ATMALDH1A1PKMCSF1R | |
| SCHEMBL7457663 | 0.65 | GPR132 (0.40) | GPR132LMNAALDH1A1PKMCSF1R | |
| SCHEMBL27686945 | 0.64 | KDM4E (0.56) | CYP2D6ALDH1A1PKMKDM4ECHRM2 | |
| SCHEMBL9037973 | 0.64 | LMNA (0.39) | GPR132LMNANCOA1NCOA3ALDH1A1 | |
| SCHEMBL8911540 | 0.63 | KDM4E (0.54) | CYP2D6ALDH1A1PKMKDM4E | |
| SCHEMBL1565525 | 0.62 | CYP1A2 (0.61) | LMNACYP2D6NAMPTNCOA1NCOA3 | |
| SCHEMBL31054426 | 0.61 | CHRNA7 (0.53) | CYP2D6ALDH1A1PKMKDM4ECHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5808062-A | AIDS THERAPY | WARNER-LAMBERT COMPANY (US) | 1998-09-15 | — | — | US | claimed |
| US-5808062-A | AIDS THERAPY | WARNER-LAMBERT COMPANY (US) | 1998-09-15 | — | — | US | disclosed |